Table of Contents

March 01 2021; volume 70 issue 3

Perspectives in Diabetes

Open Access
Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors
Aoyuan Cui, Dong Ding and Yu Li

Diabetes 2021 Mar; 70 (3): 653-664. https://doi.org/10.2337/dbi20-0006

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Metabolism

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Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
Federico Cividini, Brian T. Scott, Jorge Suarez, Darren E. Casteel, Sven Heinz, Anzhi Dai, Tanja Diemer, Jorge A. Suarez, Christopher W. Benner, Majid Ghassemian and Wolfgang H. Dillmann

Diabetes 2021 Mar; 70 (3): 665-679. https://doi.org/10.2337/db20-0779

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Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance
Regine Å. Jersin, Divya Sri Priyanka Tallapragada, André Madsen, Linn Skartveit, Even Fjære, Adrian McCann, Laurence Dyer, Aron Willems, Jan-Inge Bjune, Mona S. Bjune, Villy Våge, Hans Jørgen Nielsen, Håvard Luong Thorsen, Bjørn Gunnar Nedrebø, Christian Busch, Vidar M. Steen, Matthias Blüher, Peter Jacobson, Per-Arne Svensson, Johan Fernø, Mikael Rydén, Peter Arner, Ottar Nygård, Melina Claussnitzer, Ståle Ellingsen, Lise Madsen, Jørn V. Sagen, Gunnar Mellgren and Simon N. Dankel

Diabetes 2021 Mar; 70 (3): 680-695. https://doi.org/10.2337/db20-0096

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Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
Wang Liao, Wanbao Yang, Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun and Shaodong Guo

Diabetes 2021 Mar; 70 (3): 696-709. https://doi.org/10.2337/db20-0954

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Signal Transduction

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Activation of dsRNA-Dependent Protein Kinase R by miR-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance
Hao Wang, Yongyan Song, Yuxin Wu, Virender Kumar, Ram I. Mahato and Qiaozhu Su

Diabetes 2021 Mar; 70 (3): 710-719. https://doi.org/10.2337/db20-0181

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Obesity Studies

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Deficiency of Stat1 in CD11c⁺ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet
Antu Antony, Zeqin Lian, Xiaoyuan Dai Perrard, Jerry Perrard, Hua Liu, Aaron R. Cox, Pradip Saha, Lothar Hennighausen, Sean M. Hartig, Christie M. Ballantyne and Huaizhu Wu

Diabetes 2021 Mar; 70 (3): 720-732. https://doi.org/10.2337/db20-0634

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Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver
Sunmi Seok, Hao Sun, Young-Chae Kim, Byron Kemper and Jongsook Kim Kemper

Diabetes 2021 Mar; 70 (3): 733-744. https://doi.org/10.2337/db20-0856

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Placental Insulin/IGF-1 Signaling, PGC-1α, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4–6 Years of Age: The ECHO Healthy Start Cohort
Madeline Rose Keleher, Kathryn Erickson, Harry A. Smith, Katerina J. Kechris, Ivana V. Yang, Dana Dabelea, Jacob E. Friedman, Kristen E. Boyle and Thomas Jansson

Diabetes 2021 Mar; 70 (3): 745-751. https://doi.org/10.2337/db20-0902

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Immunology and Transplantation

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One in Ten CD8⁺ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI_15-24
Teresa Rodriguez-Calvo, Lars Krogvold, Natalie Amirian, Knut Dahl-Jørgensen and Matthias von Herrath

Diabetes 2021 Mar; 70 (3): 752-758. https://doi.org/10.2337/db20-0908

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Complications

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Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker–Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19
Sri Nagarjun Batchu, Harmandeep Kaur, Veera Ganesh Yerra, Suzanne L. Advani, M. Golam Kabir, Youan Liu, Thomas Klein and Andrew Advani

Diabetes 2021 Mar; 70 (3): 759-771. https://doi.org/10.2337/db20-0765

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Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis
Arpeeta Sharma, Judy S.Y. Choi, Nada Stefanovic, Annas Al-Sharea, Daniel S. Simpson, Nigora Mukhamedova, Karin Jandeleit-Dahm, Andrew J. Murphy, Dmitri Sviridov, James E. Vince, Rebecca H. Ritchie and Judy B. de Haan

Diabetes 2021 Mar; 70 (3): 772-787. https://doi.org/10.2337/db20-0357

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Open Access
Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin
Jianglei Chen, Yan Shao, Temmy Sasore, Gennadiy Moiseyev, Kelu Zhou, Xiang Ma, Yanhong Du and Jian-xing Ma

Diabetes 2021 Mar; 70 (3): 788-799. https://doi.org/10.2337/db20-0609

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Pharmacology and Therapeutics

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SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
Katrine M. Lauritsen, Bent R.R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Møller, Lars C. Gormsen and Esben Søndergaard

Diabetes 2021 Mar; 70 (3): 800-808. https://doi.org/10.2337/db20-0921

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Genetics/Genomes/Proteomics/Metabolomics

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Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population
Yumin Ma, Yingying Luo, Siqian Gong, Xianghai Zhou, Yufeng Li, Wei Liu, Simin Zhang, Xiaoling Cai, Qian Ren, Lingli Zhou, Xiuying Zhang, Yanai Wang, Xiuting Huang, Xueying Gao, Mengdie Hu, Xueyao Han and Linong Ji

Diabetes 2021 Mar; 70 (3): 809-816. https://doi.org/10.2337/db20-0564

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Errata

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Erratum. The Hypothalamic Arcuate Nucleus–Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes 2019;68:1054–1061
Jenny M. Brown, Jarrad M. Scarlett, Miles E. Matsen, Hong T. Nguyen, Anna Secher, Rasmus Jorgensen, Gregory J. Morton and Michael W. Schwartz

Diabetes 2021 Mar; 70 (3): 817. https://doi.org/10.2337/db21-er03a

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Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745
Zoi Michailidou, Nicholas M. Morton, José Maria Moreno Navarrete, Christopher C. West, Kenneth J. Stewart, José Manuel Fernández-Real, Christopher J. Schofield, Jonathan R. Seckl and Peter J. Ratcliffe

Diabetes 2021 Mar; 70 (3): 818. https://doi.org/10.2337/db21-er03b

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Issues and Events

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Issues and Events
Diabetes 2021 Mar; 70 (3): 819. https://doi.org/10.2337/db21ie03

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