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Pathophysiology

Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes

  1. Daniel Espes1,2⇑,
  2. Per-Ola Carlsson1,2,
  3. Ram Kumar Selvaraju3,
  4. Maria Rosestedt3,
  5. Pierre Cheung3,
  6. Håkan Ahlström4,5,
  7. Olle Korsgren6⇑ and
  8. Olof Eriksson3⇑
  1. 1Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
  2. 2Department of Medical Sciences, Uppsala University, Uppsala, Sweden
  3. 3Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
  4. 4Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  5. 5Antaros Medical AB, Mölndal, Sweden
  6. 6Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
  1. Corresponding authors: Daniel Espes, daniel.espes{at}igp.uu.se, Olle Korsgren, olle.korsgren{at}igp.uu.se, and Olof Eriksson, olof.eriksson{at}ilk.uu.se
Diabetes 2021 Apr; 70(4): 966-975. https://doi.org/10.2337/db20-0776
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Abstract

The longitudinal alterations of the pancreatic β-cell and islet mass in the progression of type 1 diabetes (T1D) are still poorly understood. The objective of this study was to repeatedly assess the endocrine volume and the morphology of the pancreas for up to 24 months after T1D diagnosis (n = 16), by 11C-5-hydroxytryptophan (11C-5-HTP) positron emission tomography (PET) and MRI. Study participants were examined four times by PET/MRI: at recruitment and then after 6, 12, and 24 months. Clinical examinations and assessment of β-cell function by a mixed-meal tolerance test and fasting blood samples were performed in connection with the imaging examination. Pancreas volume has a tendency to decrease from 50.2 ± 10.3 mL at T1D debut to 42.2 ± 14.6 mL after 24 months (P < 0.098). Pancreas uptake of 11C-5-HTP (e.g., the volume of the endocrine pancreas) did not decrease from T1D diagnosis (0.23 ± 0.10 % of injected dose) to 24-month follow-up, 0.21 ± 0.14% of injected dose, and exhibited low interindividual changes. Pancreas perfusion was unchanged from diagnosis to 24-month follow-up. The pancreas uptake of 11C-5-HTP correlated with the long-term metabolic control as estimated by HbA1c (P < 0.05). Our findings argue against a major destruction of β-cell or islet mass in the 2-year period after diagnosis of T1D.

  • Received July 27, 2020.
  • Accepted January 18, 2021.
  • © 2021 by the American Diabetes Association
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Diabetes: 70 (4)

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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Daniel Espes, Per-Ola Carlsson, Ram Kumar Selvaraju, Maria Rosestedt, Pierre Cheung, Håkan Ahlström, Olle Korsgren, Olof Eriksson
Diabetes Apr 2021, 70 (4) 966-975; DOI: 10.2337/db20-0776

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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Daniel Espes, Per-Ola Carlsson, Ram Kumar Selvaraju, Maria Rosestedt, Pierre Cheung, Håkan Ahlström, Olle Korsgren, Olof Eriksson
Diabetes Apr 2021, 70 (4) 966-975; DOI: 10.2337/db20-0776
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