The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Gregor Sachse; Elizabeth Haythorne; Thomas Hill; Peter Proks; Russell Joynson; Raul Terrón-Expósito; Liz Bentley; Stephen J. Tucker; Roger D. Cox; Frances M. Ashcroft

doi:10.2337/db20-0691

Original Research

The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion

Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft

Diabetes 2021 Feb; db200691. https://doi.org/10.2337/db20-0691

Article Information

DOI

https://doi.org/10.2337/db20-0691

PubMed

33568422

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received July 1, 2020
Accepted February 4, 2021
Published online ahead of print February 10, 2021.

© 2021 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

Author Information

Gregor Sachse^a ⇑,
Elizabeth Haythorne^a,
Thomas Hill^a,
Peter Proks^a,^b,
Russell Joynson^c,
Raul Terrón-Expósito^a,
Liz Bentley^c,
Stephen J. Tucker^b,
Roger D. Cox^c and
Frances M. Ashcroft^a

^aDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
^bDepartment of Physics, University of Oxford, Oxford OX1 3PUT, UK
^cMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK.