RT Journal Article
SR Electronic
T1 Increased Frequency of Apolipoprotein ∈<sub>4</sub> Allele in Type II Diabetes With Hypercholesterolemia
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1301
OP 1306
DO 10.2337/diab.36.11.1301
VO 36
IS 11
A1 Eto, Masaaki
A1 Watanabe, Kiyoshi
A1 Iwashima, Yasunori
A1 Morikawa, Akizuki
A1 Chonan, Norihide
A1 Oshima, Eiji
A1 Sekiguchi, Masatomo
A1 Ishii, Kaneo
YR 1987
UL http://diabetes.diabetesjournals.org/content/36/11/1301.abstract
AB The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulindependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type lib hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, apoE4/4, and apoE4/2) were highest in the type IIa group (51.4%), followed by the type Mb group (38.1%) and the normolipidemic group (16.4%), respectively, whereas the frequency of the most common phenotype, apoE3/3, was lowest in the type IIa group (48.6%), followed by the type lib group (61.9%) and the normolipidemic group (79.9%), respectively. There were significant differences in the apoE phenotype frequencies between the normolipidemic group and the type IIa and Mb groups. The frequency of the ∈4 allele was significantly higher in the type IIa (28.6%) and Mb (20.2%) groups than in the normolipidemic group (8.9%), whereas the frequency of the ∈3 allele was significantly lower in the type IIa (71.4%) and Mb (78.6%) groups than in the normolipidemic group (89.2%). The frequency of the ∈2 allele tended to be lower in diabetic patients with hypercholesterolemia. In addition, these frequencies were also examined in nondiabetic subjects (n = 59). The frequency of the ∈4 allele tended to be higher in hypercholesterolemic diabetic subjects (24.1%) than in hypercholesterolemicnondiabetic subjects (15.3%). These data suggest that diabetic patients with the ∈4 allele may be more susceptible to hypercholesterolemia than diabetic patients without the ∈4 allele and possibly nondiabetic subjects with the ∈4 allele, although the underlying mechanism is unknown.