RT Journal Article
SR Electronic
T1 Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1623
OP 1629
DO 10.2337/diab.38.12.1623
VO 38
IS 12
A1 Voorbij, Hieronymus A M
A1 Jeucken, Pieter H M
A1 Kabel, Peter J
A1 Haan, Meeny De
A1 Drexhage, Hemmo A
YR 1989
UL http://diabetes.diabetesjournals.org/content/38/12/1623.abstract
AB Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease whose notorious pathologic feature is insulitis accompanied by destruction of β-cells. In this morphological study, we examined the pancreatic events during the onset of diabetes in spontaneously diabetic BB/Organon rats. Dendritic cells were the first cells to accumulate around the islets, followed by lymphocytes. Scavenger macrophages and MHC class II-positive β-cells were only seen late in the disease. These observations suggest a role for antigen-presenting dendritic cells in the onset of the β-cell-specific autoimmune reaction and emphasize the necessity to distinguish between the several monocyte-macrophage subtypes in studies on the pathogenesis of IDDM.