RT Journal Article
SR Electronic
T1 Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 23
OP 27
DO 10.2337/diab.45.1.23
VO 45
IS 1
A1 Leturque, Armelle
A1 Loizeau, Martine
A1 Vaulont, Sophie
A1 Salminen, Marjo
A1 Girard, Jean
YR 1996
UL http://diabetes.diabetesjournals.org/content/45/1/23.abstract
AB To investigate the role of glucose transporter expression in whole-body glucose homeostasis, we have created transgenic mice that have a 2.0- to 3.5-fold increase in GLUT4 glucose transporter level in skeletal muscle and heart. This increase is sufficient to significantly improve insulin action and to reduce basal blood glucose levels in transgenic streptozotocin-induced diabetic mice. These results provide the first evidence of a direct causality between skeletal muscle GLUT4 transporter level and overall insulin responsiveness.