RT Journal Article SR Electronic T1 Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene JF Diabetes JO Diabetes FD American Diabetes Association SP 695 OP 700 DO 10.2337/diab.46.4.695 VO 46 IS 4 A1 Denny, Paul A1 Lord, Christopher J A1 Hill, Natasha J A1 Goy, Juliet V A1 Levy, Elaine R A1 Podolin, Patricia L A1 Peterson, Laurence B A1 Wicker, Linda S A1 Todd, John A A1 Lyons, Paul A YR 1997 UL http://diabetes.diabetesjournals.org/content/46/4/695.abstract AB Currently, 16 loci that contribute to the development of IDDM in the NOD mouse have been mapped by linkage analysis. To fine map these loci, we used congenic mapping. Using this approach, we localized the Idd3 locus to a 0.35-cM interval on chromosome 3 containing the Il2 gene. Segregation analysis of the known variations within this interval indicated that only one variant, a serine-to-proline substitution at position 6 of the mature interleukin-2 (IL-2) protein, consistently segregates with IDDM in crosses between NOD and a series of nondiabetic mouse strains. These data, taken together with the immunomodulatory role of IL-2, provide circumstantial evidence in support of the hypothesis that Idd3 is an allelic variation of the Il2 gene, or a variant in strong linkage disequilibrium.