PT  - JOURNAL ARTICLE
AU  - Matschinsky, F M
AU  - Glaser, B
AU  - Magnuson, M A
TI  - Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.
AID  - 10.2337/diabetes.47.3.307
DP  - 1998 Mar 01
TA  - Diabetes
PG  - 307--315
VI  - 47
IP  - 3
4099  - http://diabetes.diabetesjournals.org/content/47/3/307.short
4100  - http://diabetes.diabetesjournals.org/content/47/3/307.full
SO  - Diabetes1998 Mar 01; 47
AB  - There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of glucokinase enzyme kinetics, offers some pertinent biochemical genetic considerations, takes stock of the current experimental database of the field by emphasizing human studies and referring to recent mouse studies, and ventures a few extrapolations into the future of this endeavor.