RT Journal Article
SR Electronic
T1 Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 307
OP 315
DO 10.2337/diabetes.47.3.307
VO 47
IS 3
A1 Matschinsky, F M
A1 Glaser, B
A1 Magnuson, M A
YR 1998
UL http://diabetes.diabetesjournals.org/content/47/3/307.abstract
AB There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of glucokinase enzyme kinetics, offers some pertinent biochemical genetic considerations, takes stock of the current experimental database of the field by emphasizing human studies and referring to recent mouse studies, and ventures a few extrapolations into the future of this endeavor.