RT Journal Article
SR Electronic
T1 Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 2734
OP 2741
DO 10.2337/diabetes.51.9.2734
VO 51
IS 9
A1 Nishizawa, Hitoshi
A1 Shimomura, Iichiro
A1 Kishida, Ken
A1 Maeda, Norikazu
A1 Kuriyama, Hiroshi
A1 Nagaretani, Hiroyuki
A1 Matsuda, Morihiro
A1 Kondo, Hidehiko
A1 Furuyama, Naoki
A1 Kihara, Shinji
A1 Nakamura, Tadashi
A1 Tochino, Yoshihiro
A1 Funahashi, Tohru
A1 Matsuzawa, Yuji
YR 2002
UL http://diabetes.diabetesjournals.org/content/51/9/2734.abstract
AB Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 ± 11.9 years [mean ± SD]) than in 137 women (53.2 ± 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.