PT  - JOURNAL ARTICLE
AU  - Renström, Erik
AU  - Barg, Sebastian
AU  - Thévenod, Frank
AU  - Rorsman, Patrik
TI  - Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K<sup>+</sup> Channel–Independent Action
AID  - 10.2337/diabetes.51.2007.S33
DP  - 2002 Feb 01
TA  - Diabetes
PG  - S33--S36
VI  - 51
IP  - suppl 1
4099  - http://diabetes.diabetesjournals.org/content/51/suppl_1/S33.short
4100  - http://diabetes.diabetesjournals.org/content/51/suppl_1/S33.full
SO  - Diabetes2002 Feb 01; 51
AB  - Several reports indicate that hypoglycemic sulfonylureas augment Ca2+-dependent insulin secretion via mechanisms other than inhibition of the ATP-sensitive K+ channel. The effect involves a 65-kd protein in the granule membrane and culminates in intragranular acidification. Lowering of granule pH is necessary for the insulin granule to gain release competence. Proton pumping into the granule is driven by a v-type H+-ATPase, but requires simultaneous Cl− uptake into the granule via metabolically regulated ClC-3 Cl− channels to maintain electroneutrality. Here we discuss the possibility that modulation of granule ClC-3 channels represents the mechanism whereby sulfonylureas directly potentiate the β-cell exocytotic machinery.