PT  - JOURNAL ARTICLE
AU  - Engström, Gunnar
AU  - Stavenow, Lars
AU  - Hedblad, Bo
AU  - Lind, Peter
AU  - Eriksson, Karl-Fredrik
AU  - Janzon, Lars
AU  - Lindgärde, Folke
TI  - Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke
AID  - 10.2337/diabetes.52.2.442
DP  - 2003 Feb 01
TA  - Diabetes
PG  - 442--447
VI  - 52
IP  - 2
4099  - http://diabetes.diabetesjournals.org/content/52/2/442.short
4100  - http://diabetes.diabetesjournals.org/content/52/2/442.full
SO  - Diabetes2003 Feb 01; 52
AB  - This study explores the relationship of inflammation-sensitive plasma proteins (ISPs) with the prevalence of diabetes and the interrelationships between ISPs and diabetes in the prediction of death and incidence of myocardial infarction and stroke. Plasma levels of fibrinogen, α1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were assessed in 6,050 men, aged 28–61 years. All-cause and cardiovascular mortality and incidence of myocardial infarction and stroke were monitored over 18.7 ± 3.7 years. Prevalence of diabetes (n = 321) was significantly associated with ISP levels among overweight and obese men but not among men with BMI <25 kg/m2. The association was similar for insulin resistance according to homeostasis model assessment. High ISP levels (two or more ISPs in the top quartile) increased the cardiovascular risk among diabetic men. The risk factor-adjusted relative risks for cardiovascular mortality, myocardial infarction, and stroke were 2.8 (CI 1.8–4.5), 2.2 (1.5–3.2), and 2.5 (1.4–4.6), respectively, for diabetic men with high ISP levels (reference: nondiabetic men with low ISP levels). The corresponding risks for diabetic men with low ISP levels were 1.8 (1.1–3.0), 1.3 (0.8–2.1), and 1.2 (0.6–2.5), respectively. In conclusion, in this population-based cohort, diabetes was associated with increased ISP levels among overweight and obese men but not among men with normal weight. High ISP levels increased the cardiovascular risk similarly in diabetic as compared with nondiabetic men.