RT Journal Article
SR Electronic
T1 Promoter Polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) Genes Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1872
OP 1876
DO 10.2337/diabetes.52.7.1872
VO 52
IS 7
A1 Kubaszek, Agata
A1 Pihlajamäki, Jussi
A1 Komarovski, Vladislav
A1 Lindi, Virpi
A1 Lindström, Jaana
A1 Eriksson, Johan
A1 Valle, Timo T.
A1 Hämäläinen, Helena
A1 Ilanne-Parikka, Pirjo
A1 Keinänen-Kiukaanniemi, Sirkka
A1 Tuomilehto, Jaakko
A1 Uusitupa, Matti
A1 Laakso, Markku
YR 2003
UL http://diabetes.diabetesjournals.org/content/52/7/1872.abstract
AB High levels of cytokines are risk factors for type 2 diabetes. Therefore, we investigated whether the promoter polymorphisms of the tumor necrosis factor-α (TNF-α; G-308A) and interleukin 6 (IL-6; C-174G) genes predict the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish Diabetes Prevention Study. Altogether, 490 overweight subjects with IGT whose DNA was available were randomly divided into one of the two treatment assignments: the control group and the intensive, individualized diet and exercise intervention group. The −308A allele of the TNF-α gene was associated with an approximate twofold higher risk for type 2 diabetes compared with the G-308G genotype (odds ratio 1.80, 95% CI 1.05–3.09; P = 0.034). Subjects with both the A allele of the TNF-α gene and the C-174C genotype of the IL-6 gene had a 2.2-fold (CI 1.02–4.85, P = 0.045) higher risk of developing type 2 diabetes than subjects without the risk genotypes. We conclude that the −308A allele of the promoter polymorphism (G-308A) of the TNF-α gene is a predictor for the conversion from IGT to type 2 diabetes. Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene.