RT Journal Article SR Electronic T1 Genetic Variation of the GLUT10 Glucose Transporter (SLC2A10) and Relationships to Type 2 Diabetes and Intermediary Traits JF Diabetes JO Diabetes FD American Diabetes Association SP 2445 OP 2448 DO 10.2337/diabetes.52.9.2445 VO 52 IS 9 A1 Andersen, Gitte A1 Rose, Christian Schack A1 Hamid, Yasmin Hassan A1 Drivsholm, Thomas A1 Borch-Johnsen, Knut A1 Hansen, Torben A1 Pedersen, Oluf YR 2003 UL http://diabetes.diabetesjournals.org/content/52/9/2445.abstract AB The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The gene was examined in 61 Danish type 2 diabetic patients, and a total of six variants (−27C→T, Ala206Thr, Ala272Ala, IVS2 + 10G→A, IVS4 + 18T→G, and IVS4 + 26G→A) were identified and investigated in an association study, which included 503 type 2 diabetic patients and 510 glucose-tolerant control subjects. None of the variants were associated with type 2 diabetes. Interestingly, carriers of the codon 206 Thr allele had 18% lower fasting serum insulin levels (P = 0.002) and 20% lower insulinogenic index (P = 0.03) than homozygous carriers of the Ala allele. These results suggest that variation in the coding region of SLC2A10 does not contribute substantially to the pathogenesis of type 2 diabetes in the examined study population. However, the codon 206 polymorphism may be related to the interindividual variation in fasting and oral glucose-induced serum insulin levels.