RT Journal Article SR Electronic T1 Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese JF Diabetes JO Diabetes FD American Diabetes Association SP 228 OP 234 DO 10.2337/diabetes.53.1.228 VO 53 IS 1 A1 Xiang, Kunsan A1 Wang, Yanqing A1 Zheng, Taishan A1 Jia, Weiping A1 Li, Jie A1 Chen, Lei A1 Shen, Kunxue A1 Wu, Songhua A1 Lin, Xin A1 Zhang, Guodong A1 Wang, Congrong A1 Wang, Suijun A1 Lu, Huijuan A1 Fang, Qichen A1 Shi, Yi A1 Zhang, Rong A1 Xu, Jing A1 Weng, Qin YR 2004 UL http://diabetes.diabetesjournals.org/content/53/1/228.abstract AB This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogenous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showing linkage to type 2 diabetes/IGH from the entire sample group analysis was located on chromosome 6q21-q23 (128.93 cM, 1-LOD [logarithm of odds] support interval between 124 and 142 cM, according to the Marshfield genetic map), with a maximum likelihood score of 6.23, a nonparametric linkage (all) score of 4.48, and empirical P value <0.001. With a subanalysis based on 101 affected sibpairs with age at diagnosis of type 2 diabetes/IGH <40 years, we detected significant evidence for linkage to chromosome 1q21-q24 (192.1 cM, 1-LOD support interval between 182 and 197 cM), with a maximum likelihood score of 8.91, a nonparametric linkage (all) score of 5.70, and empirical P value <0.001. No interaction was observed between these two regions. Our independent replication of the region on chromosome 1q that has been shown to be linked significantly to type 2 diabetes/IGH in Chinese supports the notion that gene(s) in this region may be universally important in the development of human type 2 diabetes.