RT Journal Article
SR Electronic
T1 Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 228
OP 234
DO 10.2337/diabetes.53.1.228
VO 53
IS 1
A1 Xiang, Kunsan
A1 Wang, Yanqing
A1 Zheng, Taishan
A1 Jia, Weiping
A1 Li, Jie
A1 Chen, Lei
A1 Shen, Kunxue
A1 Wu, Songhua
A1 Lin, Xin
A1 Zhang, Guodong
A1 Wang, Congrong
A1 Wang, Suijun
A1 Lu, Huijuan
A1 Fang, Qichen
A1 Shi, Yi
A1 Zhang, Rong
A1 Xu, Jing
A1 Weng, Qin
YR 2004
UL http://diabetes.diabetesjournals.org/content/53/1/228.abstract
AB This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogenous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showing linkage to type 2 diabetes/IGH from the entire sample group analysis was located on chromosome 6q21-q23 (128.93 cM, 1-LOD [logarithm of odds] support interval between 124 and 142 cM, according to the Marshfield genetic map), with a maximum likelihood score of 6.23, a nonparametric linkage (all) score of 4.48, and empirical P value <0.001. With a subanalysis based on 101 affected sibpairs with age at diagnosis of type 2 diabetes/IGH <40 years, we detected significant evidence for linkage to chromosome 1q21-q24 (192.1 cM, 1-LOD support interval between 182 and 197 cM), with a maximum likelihood score of 8.91, a nonparametric linkage (all) score of 5.70, and empirical P value <0.001. No interaction was observed between these two regions. Our independent replication of the region on chromosome 1q that has been shown to be linked significantly to type 2 diabetes/IGH in Chinese supports the notion that gene(s) in this region may be universally important in the development of human type 2 diabetes.