PT  - JOURNAL ARTICLE
AU  - Ng, Maggie C.Y.
AU  - So, Wing-Yee
AU  - Cox, Nancy J.
AU  - Lam, Vincent K.L.
AU  - Cockram, Clive S.
AU  - Critchley, Julian A.J.H.
AU  - Bell, Graeme I.
AU  - Chan, Juliana C.N.
TI  - Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25
AID  - 10.2337/diabetes.53.6.1609
DP  - 2004 Jun 01
TA  - Diabetes
PG  - 1609--1613
VI  - 53
IP  - 6
4099  - http://diabetes.diabetesjournals.org/content/53/6/1609.short
4100  - http://diabetes.diabetesjournals.org/content/53/6/1609.full
SO  - Diabetes2004 Jun 01; 53
AB  - We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of ≤40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [LOD] >0.59, Ppointwise < 0.05): chromosome 1 at 173.9 cM (LOD = 3.09), chromosome 3 at 26.3 cM (LOD = 1.27), chromosome 4 at 135.3 cM (LOD = 2.63), chromosome 5 at 139.3 cM (LOD = 0.84), chromosome 6 at 178.9 cM (LOD = 1.91), chromosome 12 at 48.7 cM (LOD = 1.99), and chromosome 18 at 28.1 cM (LOD = 1.00). Simulation studies showed genome-wide significant evidence for linkage of the chromosome 1 region (Pgenome-wide = 0.036). We have confirmed the results of previous studies for the presence of a susceptibility locus on chromosome 1q21-q25 (173.9 cM) and suggest the locations of other loci that may contribute to the development of type 2 diabetes in Hong Kong Chinese.