RT Journal Article SR Electronic T1 Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity JF Diabetes JO Diabetes FD American Diabetes Association SP 1554 OP 1561 DO 10.2337/db06-0133 VO 55 IS 6 A1 Cancello, Raffaella A1 Tordjman, Joan A1 Poitou, Christine A1 Guilhem, Gaël A1 Bouillot, Jean Luc A1 Hugol, Danielle A1 Coussieu, Christiane A1 Basdevant, Arnaud A1 Hen, Avner Bar A1 Bedossa, Pierre A1 Guerre-Millo, Michèle A1 Clément, Karine YR 2006 UL http://diabetes.diabetesjournals.org/content/55/6/1554.abstract AB In human obesity, white adipose tissue (WAT) is enriched in macrophages. How macrophage infiltration in WAT contributes to the complications of obesity is unknown. This study tested the hypothesis that recruitment of macrophages in omental WAT is associated with hepatic damage in obese patients. Paired biopsies of subcutaneous and omental WAT and a liver biopsy were collected during gastric surgery in 46 obese women and 9 obese men (BMI 47.9 ± 0.93 kg/m2). The number of HAM56+ macrophages in WAT was quantified microscopically, and correlations with clinical and biological parameters and histological liver pathology were investigated. There were twice as many macrophages in omental as in subcutaneous WAT (P < 0.0001). After adjustment for age, omental WAT macrophage infiltration was correlated to fasting glucose and insulin, quantitative insulin sensitivity check index, triglycerides, aspartate aminotransferase (AST), and γ-glutamyltranspeptidase. We propose an easy equation to estimate the amount of macrophages in omental WAT. Increased macrophage accumulation specifically in omental WAT was associated with hepatic fibroinflammatory lesions (P = 0.01). The best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and omental WAT macrophages. These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients.