RT Journal Article
SR Electronic
T1 Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1554
OP 1561
DO 10.2337/db06-0133
VO 55
IS 6
A1 Cancello, Raffaella
A1 Tordjman, Joan
A1 Poitou, Christine
A1 Guilhem, Gaël
A1 Bouillot, Jean Luc
A1 Hugol, Danielle
A1 Coussieu, Christiane
A1 Basdevant, Arnaud
A1 Hen, Avner Bar
A1 Bedossa, Pierre
A1 Guerre-Millo, Michèle
A1 Clément, Karine
YR 2006
UL http://diabetes.diabetesjournals.org/content/55/6/1554.abstract
AB In human obesity, white adipose tissue (WAT) is enriched in macrophages. How macrophage infiltration in WAT contributes to the complications of obesity is unknown. This study tested the hypothesis that recruitment of macrophages in omental WAT is associated with hepatic damage in obese patients. Paired biopsies of subcutaneous and omental WAT and a liver biopsy were collected during gastric surgery in 46 obese women and 9 obese men (BMI 47.9 ± 0.93 kg/m2). The number of HAM56+ macrophages in WAT was quantified microscopically, and correlations with clinical and biological parameters and histological liver pathology were investigated. There were twice as many macrophages in omental as in subcutaneous WAT (P < 0.0001). After adjustment for age, omental WAT macrophage infiltration was correlated to fasting glucose and insulin, quantitative insulin sensitivity check index, triglycerides, aspartate aminotransferase (AST), and γ-glutamyltranspeptidase. We propose an easy equation to estimate the amount of macrophages in omental WAT. Increased macrophage accumulation specifically in omental WAT was associated with hepatic fibroinflammatory lesions (P = 0.01). The best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and omental WAT macrophages. These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients.