RT Journal Article
SR Electronic
T1 Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 486
OP 494
DO 10.2337/db09-1166
VO 59
IS 2
A1 Cardwell, Chris R.
A1 Stene, Lars C.
A1 Joner, Geir
A1 Bulsara, Max K.
A1 Cinek, Ondrej
A1 Rosenbauer, Joachim
A1 Ludvigsson, Johnny
A1 Jané, Mireia
A1 Svensson, Jannet
A1 Goldacre, Michael J.
A1 Waldhoer, Thomas
A1 Jarosz-Chobot, Przemysława
A1 Gimeno, Suely G.A.
A1 Chuang, Lee-Ming
A1 Parslow, Roger C.
A1 Wadsworth, Emma J.K.
A1 Chetwynd, Amanda
A1 Pozzilli, Paolo
A1 Brigis, Girts
A1 Urbonaitė, Brone
A1 Šipetić, Sandra
A1 Schober, Edith
A1 Devoti, Gabriele
A1 Ionescu-Tirgoviste, Constantin
A1 de Beaufort, Carine E.
A1 Stoyanov, Denka
A1 Buschard, Karsten
A1 Patterson, Chris C.
YR 2010
UL http://diabetes.diabetesjournals.org/content/59/2/486.abstract
AB OBJECTIVE The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2–9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age. © 2010 by the American Diabetes Association.