RT Journal Article SR Electronic T1 Glucose Variability JF Diabetes JO Diabetes FD American Diabetes Association SP 1398 OP 1404 DO 10.2337/db12-1396 VO 62 IS 5 A1 Service, F. John YR 2013 UL http://diabetes.diabetesjournals.org/content/62/5/1398.abstract AB The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.