RT Journal Article
SR Electronic
T1 Glucose Variability
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1398
OP 1404
DO 10.2337/db12-1396
VO 62
IS 5
A1 Service, F. John
YR 2013
UL http://diabetes.diabetesjournals.org/content/62/5/1398.abstract
AB The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.