RT Journal Article
SR Electronic
T1 Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-wide Association Studies
JF Diabetes
JO Diabetes
FD American Diabetes Association
DO 10.2337/db07-0482
A1 Hayes, M. Geoffrey
A1 Pluzhnikov, Anna
A1 Miyake, Kazuaki
A1 Sun, Ying
A1 Ng, Maggie C.Y.
A1 Roe, Cheryl A.
A1 Below, Jennifer E.
A1 Nicolae, Raluca I.
A1 Konkashbaev, Anuar
A1 Bell, Graeme I.
A1 Cox, Nancy J.
A1 Hanis, Craig L.
YR 2007
UL http://diabetes.diabetesjournals.org/content/early/2007/09/10/db07-0482.abstract
AB OBJECTIVE: To identify DNA polymorphisms associated with type 2 diabetes (T2D) in a Mexican American (MA) population. RESEARCH DESIGN AND METHODS: We genotyped 116,204 single nucleotide polymorphisms (SNPs) in 281 MA with T2D and 280 random MA from Starr County, Texas using the Affymetrix GeneChip® Human Mapping 100K Set. Allelic association exact tests were calculated. Our most significant SNPs were compared to results from other T2D genome-wide association studies (GWAS). Proportions of African, European, and Asian ancestry were estimated from the HapMap samples using structure for each individual to rule out spurious association due to population substructure. RESULTS: We observed more significant allelic associations than expected genome-wide as empirically assessed by permutation [14 below a p of 1x10-4 (8.7 expected)]. No significant differences were observed between the proportion of ancestry estimates in the case and random control sets suggesting the association results were not likely confounded by substructure. A query of our top ∼1% of SNPs (p<0.01) revealed SNPs in or near four genes that showed evidence for association (p<0.05) in multiple other GWAS interrogated: rs979752 and rs10500641 near UBQLNL and OR52H1 on chromosome 11, rs2773080 and rs3922812 in or near RALGPS2 on chromosome 1, and rs1509957 near EGR2 on chromosome 10. CONCLUSIONS: We identified several SNPs with suggestive evidence for replicated association with T2D which merit further investigation. CONCLUSIONS: Abbreviations: