RT Journal Article
SR Electronic
T1 Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1841
OP 1852
DO 10.2337/db14-0988
VO 64
IS 5
A1 Fall, Tove
A1 Hägg, Sara
A1 Ploner, Alexander
A1 Mägi, Reedik
A1 Fischer, Krista
A1 Draisma, Harmen H.M.
A1 Sarin, Antti-Pekka
A1 Benyamin, Beben
A1 Ladenvall, Claes
A1 Åkerlund, Mikael
A1 Kals, Mart
A1 Esko, Tõnu
A1 Nelson, Christopher P.
A1 Kaakinen, Marika
A1 Huikari, Ville
A1 Mangino, Massimo
A1 Meirhaeghe, Aline
A1 Kristiansson, Kati
A1 Nuotio, Marja-Liisa
A1 Kobl, Michael
A1 Grallert, Harald
A1 Dehghan, Abbas
A1 Kuningas, Maris
A1 de Vries, Paul S.
A1 de Bruijn, Renée F.A.G.
A1 Willems, Sara M.
A1 Heikkilä, Kauko
A1 Silventoinen, Karri
A1 Pietiläinen, Kirsi H.
A1 Legry, Vanessa
A1 Giedraitis, Vilmantas
A1 Goumidi, Louisa
A1 Syvänen, Ann-Christine
A1 Strauch, Konstantin
A1 Koenig, Wolfgang
A1 Lichtner, Peter
A1 Herder, Christian
A1 Palotie, Aarno
A1 Menni, Cristina
A1 Uitterlinden, André G.
A1 Kuulasmaa, Kari
A1 Havulinna, Aki S.
A1 Moreno, Luis A.
A1 Gonzalez-Gross, Marcela
A1 Evans, Alun
A1 Tregouet, David-Alexandre
A1 Yarnell, John W.G.
A1 Virtamo, Jarmo
A1 Ferrières, Jean
A1 Veronesi, Giovanni
A1 Perola, Markus
A1 Arveiler, Dominique
A1 Brambilla, Paolo
A1 Lind, Lars
A1 Kaprio, Jaakko
A1 Hofman, Albert
A1 Stricker, Bruno H.
A1 van Duijn, Cornelia M.
A1 Ikram, M. Arfan
A1 Franco, Oscar H.
A1 Cottel, Dominique
A1 Dallongeville, Jean
A1 Hall, Alistair S.
A1 Jula, Antti
A1 Tobin, Martin D.
A1 Penninx, Brenda W.
A1 Peters, Annette
A1 Gieger, Christian
A1 Samani, Nilesh J.
A1 Montgomery, Grant W.
A1 Whitfield, John B.
A1 Martin, Nicholas G.
A1 Groop, Leif
A1 Spector, Tim D.
A1 Magnusson, Patrik K.
A1 Amouyel, Philippe
A1 Boomsma, Dorret I.
A1 Nilsson, Peter M.
A1 Järvelin, Marjo-Riitta
A1 Lyssenko, Valeriya
A1 Metspalu, Andres
A1 Strachan, David P.
A1 Salomaa, Veikko
A1 Ripatti, Samuli
A1 Pedersen, Nancy L.
A1 Prokopenko, Inga
A1 McCarthy, Mark I.
A1 Ingelsson, Erik
YR 2015
UL http://diabetes.diabetesjournals.org/content/64/5/1841.abstract
AB Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10−107) and stratified analyses (all P < 3.3 × 10−30). We found evidence of a causal effect of adiposity on blood pressure, fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.