RT Journal Article
SR Electronic
T1 Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 806
OP 814
DO 10.2337/db16-0779
VO 66
IS 4
A1 Al-Majdoub, Mahmoud
A1 Ali, Arslan
A1 Storm, Petter
A1 Rosengren, Anders H.
A1 Groop, Leif
A1 Spégel, Peter
YR 2017
UL http://diabetes.diabetesjournals.org/content/66/4/806.abstract
AB Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)–positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA from type 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide–driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.