RT Journal Article
SR Electronic
T1 SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP db180184
DO 10.2337/db18-0184
A1 Jiao, Yang
A1 Zhao, Jiejie
A1 Zhang, Zhijian
A1 Li, Min
A1 Yu, Xi
A1 Yang, Yanying
A1 Liu, Jie
A1 Liao, Shengjie
A1 Li, Duanzhuo
A1 Wang, Yuxing
A1 Zhang, Die
A1 Chen, Yulu
A1 Shi, Guojun
A1 Liu, Bin
A1 Lu, Yan
A1 Li, Xiaoying
YR 2018
UL http://diabetes.diabetesjournals.org/content/early/2018/08/28/db18-0184.abstract
AB Obesity is usually associated with an increased risk of non-alcoholic fatty liver disease (NAFLD) that is characterized by accumulation of excessive triglyceride in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis is poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a transcription factor that regulates cell proliferation and differentiation, play an important role in hepatic triglyceride metabolism. Sox4 expression levels are markedly upregulated in livers of obese rodents and humans. Adenovirus-medicated overexpression of Sox4 in the livers of lean mice promotes liver steatosis, whereas liver-specific knockdown of Sox4 ameliorates triglyceride accumulation and improves insulin resistance in obese mice. At the molecular level, we show that Sox4 could directly control the transcription of SREBP-1c gene, through binding to its proximal promoter region. Thus, we have identified Sox4 as an important component of hepatic triglyceride metabolism.