RT Journal Article
SR Electronic
T1 The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP 1599
OP 1604
DO 10.2337/db20-0303
VO 69
IS 8
A1 Knights, Alexander J.
A1 Wu, Jun
A1 Tseng, Yu-Hua
YR 2020
UL http://diabetes.diabetesjournals.org/content/69/8/1599.abstract
AB Adipose tissue serves as the body’s primary energy storage site; however, findings in recent decades have transformed our understanding of the multifaceted roles of this adaptable organ. The ability of adipose tissue to undergo energy expenditure through heat generation is termed adaptive thermogenesis, a process carried out by thermogenic adipocytes. Adipocytes are the primary parenchymal cell type in adipose tissue, yet these cells are sustained within a rich stromal vascular microenvironment comprised of adipose stem cells and progenitors, immune cells, neuronal cells, fibroblasts, and endothelial cells. Intricate cross talk between these diverse cell types is essential in regulating the activation of thermogenic fat, and the past decade has shed significant light on how this intercellular communication functions. This review will draw upon recent findings and current perspectives on the sophisticated repertoire of cellular and molecular features that comprise the adipose thermogenic milieu.