RT Journal Article
SR Electronic
T1 Managing Hyperglycemia in the COVID-19 Inflammatory Storm
JF Diabetes
JO Diabetes
FD American Diabetes Association
SP dbi200022
DO 10.2337/dbi20-0022
A1 Gianchandani, Roma
A1 Esfandiari, Nazanene H.
A1 Ang, Lynn
A1 Iyengar, Jennifer
A1 Knotts, Sharon
A1 Choksi, Palak
A1 Pop-Busui, Rodica
YR 2020
UL http://diabetes.diabetesjournals.org/content/early/2020/08/05/dbi20-0022.abstract
AB A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) is now at global pandemic levels causing significant morbidity and mortality. Patients with diabetes are particularly vulnerable and more likely to get severe complications when infected with this virus. Although the information continues to emerge, here we provide our perspective on initial outcomes observed in hospitalized patients with diabetes and the potential role played by the proinflammatory metabolic state in these patients that promotes fertile ground for the virus’ inflammatory surge, resulting in severe insulin resistance and severe hyperglycemia. The rapidly evolving renal failure, hypotension, pressor and steroid use, and variable nutritional support further complicates their management. Thus, timely implementation of glucose management protocols addressing these complex scenarios while also following COVID-19–related trajectories in inflammatory biomarkers and being cognizant of the health care provider exposure may substantially affect morbidity and mortality.