Table 1

Clinical characteristics of DCCT participants at DCCT baseline and closeout

Primary cohortSecondary cohort
Intensive
(N = 65)Conventional
(N = 58)P valueIntensive
(N = 57)Conventional
(N = 36)P value
DCCT baseline
 Age (years)28 ± 626 ± 70.01630 ± 730 ± 6
 Duration (months)31 ± 1927 ± 14108 ± 5190 ± 43
 A1C
  %8.8 ± 1.99.1 ± 1.98.9 ± 1.58.3 ± 1.20.022
  mmol/mol73 ± 20.876 ± 20.874 ± 16.267 ± 13.1
 Mean blood glucose (mg/dL)221 ± 83245 ± 85237 ± 76214 ± 72
 Triglycerides (mg/dL)79 ± 6665 ± 2397 ± 4886 ± 56
 Cholesterol (mg/dL)182 ± 33174 ± 32181 ± 36176 ± 37
 Retinopathy (%)
  10/10: none10010000
  20/≤20: microaneurysms only005861
  30/≤30: mild NPDR002325
  45/≤45: moderate NPDR001914
 AER >40 mg/24 h (%)1.50.010.58.3
 Confirmed clinical neuropathy (%)6.21.717.911.1
 SBP (mmHg)116 ± 10114 ± 11115 ± 12120 ± 120.042
 DBP (mmHg)73 ± 972 ± 973 ± 876 ± 10
DCCT closeout
 Age (years)34 ± 631 ± 70.01336 ± 736 ± 6
 Duration (months)101 ± 3194 ± 23189 ± 55169 ± 46
 DCCT mean A1C
  % 7.1 ± 0.89.5 ± 1.4<0.0017.1 ± 0.88.8 ± 1.5<0.001
  mmol/mol54 ± 8.780 ± 15.354 ± 8.773 ± 16.4
 Mean blood glucose (mg/dL)149 ± 48239 ± 76<0.001152 ± 46215 ± 83<0.001
 Triglycerides (mg/dL)72 ± 3576 ± 3491 ± 5778 ± 36
 Cholesterol (mg/dL)175 ± 31178 ± 33181 ± 33178 ± 33
 Retinopathy (%)0.005
  10/10: none583643
  20/≤20: microaneurysms only37413036
  30/≤30: mild NPDR2194436
  45/≤45: moderate NPDR332325
 AER >40 mg/24 h3.110.314.011.1
 Confirmed clinical neuropathy (%)2.34.812.717.1
 SBP (mmHg)115 ± 9115 ± 11118 ± 9121 ± 14
 DBP (mmHg)75 ± 974 ± 877 ± 877 ± 11
  • Data are mean ± SD, unless otherwise indicated. DBP, diastolic blood pressure; NPDR, nonproliferative diabetic retinopathy; SBP, systolic blood pressure.