Table 2

Comparison of TCR sequences from proinsulin-specific islet-infiltrating CD4+ T-cell clones

CloneTRAVTRAJTRA CDR3CDR3§TRBVTRBJTRBDTRB CDR3CDR3§Epitope HLA
1.9*20*027*01CAVQAGGNNRLAF115–1*011–2*011*01CASSLERDGYTF10VELGGGPGA DQ8
6.1526–1*0121*01CIAIYNFNKFYF105–1*011–6*022*01CASSLEASSYNSPLHF14VELGGGPGA DQ8
2.1326–1*0139*01CIVSHNAGNMLTF115–1*012–5*012*01CASSLERETQYF10VELGGGPGA DQ8
4.136*0236*01CALKYGANNLFF1018*011–1*011*01CASSPTTGGDEAFF12QVELGGGPGAG DQ8
5.526–1*0154*01CIVRVEIQGAQKLVF135–1*012–5*011*01CASSLGPGQRETQYF13QVELGGGPG DQ8
1.125*0116*01CAGGFSDGQKLLF1120–1*03–072–7*011*01CSARTEAYEQYF10AGSLQPLALE DQ8
1.220*0258*01CAVIETSGSRLTF1120–1*012–3*012*01CSARDQQRVDTQYF12AGSLQPLAL DQ8
2.419*0149*01CALSRAGTGNQFYF125–1*012–4*012*01CASSLGLRGENIQYF13SLQPLALEGS DQ8trans
  • *Four clones have these identical TCR sequences; a single example is shown.

  • †Three clones have these identical TCR sequences; a single example is shown.

  • ‡Two clones have these identical TCR sequences; a single example is shown.

  • §Number of amino acids comprising the CDR3.