Table 3

Basic characteristics and metabolic parameters in the analysis including 1-h hyperglycemia for the different groups of participants with a single defect and for NGT

NGTIFGIA1cI1hG
N (males/females)491 (324/167)275 (210/65)112 (53/59)173 (152/21)*
Basic characteristics
 Age (years)62.6 ± 6.260.8 ± 6.264.1 ± 6.861.8 ± 6.0
 BMI (kg/m2)27.1 ± 3.827.7 ± 3.327.2 ± 3.927.2 ± 3.4
 HbA1c (mmol/mol)35.2 ± 2.235.9 ± 1.839.9 ± 1.235.5 ± 2.2
Glucose, insulin, C-peptide plasma concentrations
 Gb (mmol/L)5.17 ± 0.345.86 ± 0.225.14 ± 0.345.31 ± 0.22*
 G60 (mmol/L)6.62 ± 1.147.04 ± 1.076.87 ± 1.129.94 ± 1.17*
 G120 (mmol/L)5.01 ± 1.085.14 ± 1.155.10 ± 1.155.85 ± 1.21*
 Gm (mmol/L)6.30 ± 0.766.78 ± 0.676.41 ± 0.778.09 ± 0.74*
 Ib (pmol/L)48.0 ± 29.664.7 ± 44.249.9 ± 24.649.8 ± 28.7
 Im (pmol/L)280.3 ± 167.4329.9 ± 177.0294.2 ± 178.9375.7 ± 246.1*
 CPb (pmol/L)715 ± 252853 ± 309757 ± 245743 ± 255
 CPm (pmol/L)2,408 ± 7082,608 ± 7502,470 ± 7902,766 ± 845*
Insulin sensitivity/resistance
 HOMA-IR (nondim.)1.85 ± 1.142.82 ± 1.961.91 ± 0.971.96 ± 1.13
 PREDIM (mg ⋅ kg−1 ⋅ min−1)6.11 ± 1.795.21 ± 1.395.86 ± 1.535.42 ± 1.60*
BCF and insulin secretion
 GSENS (pmol ⋅ min−1 ⋅ m−2 ⋅ mmol/L−1)133.8 ± 66.4131.2 ± 63.4124.3 ± 60.195.9 ± 37.1*
 RSENS (pmol ⋅ m−2 ⋅ mmol/L−1)1,080 ± 8231,064 ± 8041,006 ± 941853 ± 609
 PFR (nondim.)1.83 ± 0.591.86 ± 0.661.76 ± 0.841.66 ± 0.51
 ISRr (pmol ⋅ min−1 ⋅ m−2)301.9 ± 115.5260.4 ± 93.3304.5 ± 126.4206.4 ± 69.1*
 ISRb (pmol ⋅ min−1 ⋅ m−2)89.4 ± 30.9107.9 ± 38.493.9 ± 30.692.9 ± 32.0
 ISRt (nmol ⋅ m−2)43.8 ± 13.446.4 ± 14.045.1 ± 15.852.4 ± 16.4*
CLins (L ⋅ min−1 ⋅ m−2)0.09 ± 0.030.08 ± 0.020.09 ± 0.020.08 ± 0.03*
  • Data are means ± SD unless otherwise indicated. IGT was excluded because of low sample size. HbA1c (%): 5.4 ± 0.20 (NGT), 5.4 ± 0.16 (IFG), 5.8 ± 0.11 (IA1c), 5.4 ± 0.20 (I1hG) (from http://www.ngsp.org/convert1.asp). CPb, CPm, basal (fasting) and mean C-peptide, respectively; Gb, G60, G120, Gm, glucose at basal, 60 min, and 120 min and mean glucose; Ib, Im, basal and mean insulin; nondim., nondimensional.

  • * Significant difference for I1hG vs. NGT,

  • I1hG vs. IFG,

  • I1hG vs. IA1c.