Table 2

Differentially expressed genes in PLNs of 16-week-old NOD mice expressing high levels of Deaf1-Var1 versus those expressing low levels of Deaf1-Var1

Gene symbolFold changeGene description
Genes upregulated by more than fourfold
 Pdpk18.213-Phosphoinositide-dependent protein kinase-1
 1810009J06Rik7.44RIKEN cDNA 1810009J06 gene
 Ddx257.31DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
 Trim556.80Tripartite motif-containing 55
 Fbxo316.47F-box protein 31
 Hist1h1c6.38Histone cluster 1, H1c
 Otud35.99OTU domain–containing 3
 Ptms5.93Parathymosin
 Herpud15.75Homocysteine-inducible, endoplasmic reticulum stress–inducible, ubiquitin-like domain member 1
 Galntl25.39UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 gene
 Dcp25.08DCP2 decapping enzyme homolog
 H1f05.02H1 histone family, member 0
 Glul4.93Glutamate-ammonia ligase (glutamine synthetase)
 Cwc154.88CWC15 homolog
 Tfdp24.77DP-3 protein-regulating cell cycle transcription factor DRTF1/E2F
 1110006O24Rik4.75RIKEN cDNA 1110006O24 gene
 Hist1h1e4.64Histone cluster 1, H1e c
 Map3k64.58ASK2 mRNA for apoptosis signal-regulating kinase 2
 Fbxo24.55F-box protein 2
 Srsf10 (Sfrs13a)4.51FUS interacting protein (serine-arginine rich) 1
 Reg3b4.47Regenerating islet-derived 3 beta
 Txnip4.46Thioredoxin interacting protein
 Gpsm14.32G-protein signaling modulator 1
 Fhl14.30Four and a half LIM domains 1
 Bbc34.27BCL2 binding component 3
 Tfam4.23Transcription factor A, mitochondrial gene
 Klf154.19Kruppel-like factor 15
 Gm119384.13Predicted gene 11938
 Ptbp24.07Polypyrimidine tract binding protein 2
 Sesn14.05Sestrin 1
 Myo1e4.03Myosin IE
Genes downregulated by more than fourfold
 Fabp1−10.11Fatty acid binding protein 1
 Tgtp1−5.76T-cell specific GTPase 1
 BC048507−5.53cDNA sequence BC048507
 Clec2d−5.15C-type lectin domain family 2, member d
 Traf1−5.10TNF receptor-associated factor 1
 Lyl1−4.94Lymphoblastomic leukemia 1
 Neat1−4.70Nuclear paraspeckle assembly transcript 1 (nonprotein coding)
 Ms4a4b−4.61Membrane-spanning 4-domains, subfamily A, member 4B
 Amy2a5−4.44Amylase 2a5
 Ahsg−4.43alpha-2-HS-glycoprotein
 Sash3−4.35SAM and SH3 domain containing 3
 Dennd2d−4.28DENN/MADD domain containing 2D
 Dynll1−4.23Dynein light chain LC8-type 1
 Lcp1−4.22Lymphocyte cytosolic protein 1
 Alb−4.19Albumin
  • Data shown are based on the results of two individual arrays. Two-color microarrays were performed separately on PLN RNA samples from mice 1 and 2 (from Fig. 2C) with high Deaf1-Var1 expression compared with a pool of PLN RNA samples from mice 13 and 14 (from Fig. 2C) with low Deaf1-Var1 expression. Boldfaced genes were selected for further analysis.