Table 2

PHD2 (EGLN1) correlations with genes involved in the lipolytic machinery in human SAT and VAT adipose depots

Nondiabetic participantsType 2 diabetic participantsP value
N7329
Age (years)47.23 ± 12.147.55 ± 11.30.9
BMI (kg/m2)37.7 ± 11.341.6 ± 6.80.09
Fasting glucose (mg/dL)93.01 ± 12.7163.2 ± 59.8<0.0001
EGLN1 (RU) in SAT0.084 ± 0.0210.070 ± 0.0160.002
EGLN1 (RU) in VAT0.082 ± 0.0190.079 ± 0.0200.4
All participantsNondiabetic participantsType 2 diabetic participants
rP valuerP valuerP value
SAT
 Age (years)−0.0560.5−0.0470.70.0460.8
 BMI (kg/m2)0.0130.9−0.0010.9−0.030.9
 Fasting glucose (mg/dL)−0.130.2−0.0150.90.170.3
 CAV1 (RU)0.47<0.00010.46<0.00010.460.03
 ABHD5 (RU)0.320.010.340.080.110.6
 AKAP (RU)0.320.010.360.060.550.01
 ATGL (RU)0.100.4−0.100.50.120.6
 MGLL (RU)0.140.20.130.40.030.9
 PRKACA (RU)0.150.2−0.110.40.680.001
 PLIN1 (RU)−0.150.2−0.360.040.160.4
 CIDEC (RU)−0.010.9−0.120.40.120.5
 TIP47 (RU)−0.270.04−0.250.1−0.140.5
VAT
 Age (years)−0.050.60.010.9−0.170.3
 BMI (kg/m2)−0.080.4−0.060.5−0.160.3
 Fasting glucose (mg/dL)0.030.70.110.30.030.8
 CAV1 (RU)0.120.30.130.30.240.3
 ABHD5 (RU)0.070.6−0.050.80.360.2
 AKAP (RU)0.070.50.010.90.210.4
 ATGL (RU)0.070.50.100.5−0.010.9
 MGLL (RU)0.380.0040.420.0080.170.5
 PRKACA (RU)−0.060.6−0.060.6−0.120.6
 PLIN1 (RU)0.170.20.210.20.190.4
 CIDEC (RU)0.090.40.0450.70.180.4
 TIP47 (RU)0.110.3−0.020.90.380.1
  • RU, relative units; VAT, visceral adipose tissue. Boldface indicates significant P values.