Table 6

Multiple Cox regression analysis including the factors that showed significant associations to T1D when analyzed univariately

ChromosomeSNPGeneSubjects with T1D (n = 84)
vs. all other subjects (n = 5,080)*P
1p13.2rs2476601PTPN222.49 (1.74–3.55)<0.0001
3p21.31rs11711054CCR51.36 (1.00–1.86)0.0499
11p15.5rs7111341INS0.62 (0.41–0.94)0.0250
11p15.5rs1004446INS0.67 (0.47–0.95)0.0236
12q13.2rs2292239ERBB31.47 (1.08–2.00)0.0140
12q24.12rs3184504SH2B31.44 (1.06–1.96)0.0185
14q32.2rs4900384C14orf640.72 (0.51–1.02)0.0619
15q25.1rs3825932CTSH0.68 (0.49–0.96)0.0269
  • The analysis was corrected for HLA category, sex, and country for European sites as covariates. For U.S. sites, the principal components were estimated from our data from the U.S. population to be included in the model as a covariate for the two major principal components. The principal components were used to adjust for heterogeneity within the Caucasian population in the U.S. sites. The factors indicating nominal significant risk or protection are indicated in bold.

  • *HR (95% CI).