Table 3

Multiple Cox regression analysis including the factors that showed significant associations to autoantibody positivity when analyzed univariately

ChromosomeSNPGeneAutoantibody-positive subjects (n = 350)
vs. autoantibody-negative subjects (n = 4,814)*P
1p13.2rs2476601PTPN221.54 (1.26–1.87)<0.0001
1q31.2rs2816316RGS11.25 (1.04–1.51)0.0185
4p15.2rs1051708601.22 (1.04–1.43)0.0142
7p12.1rs4948088COBL0.62 (0.40–0.97)0.0346
11p15.5rs1004446INS0.77 (0.65–0.90)0.0010
12q13.2rs2292239ERBB31.31 (1.12–1.52)0.0005
12q24.12rs3184504SH2B31.38 (1.19–1.61)<0.0001
16p13.13rs12708716CLEC16A0.84 (0.71–0.98)0.0324
  • The analysis was corrected for HLA category, sex, and country for European sites as covariates. For U.S. sites, the principal components were estimated from our data from the U.S. population to be included in the model as a covariate for the two major principal components. The principal components were used to adjust for heterogeneity within the Caucasian population in the U.S. sites. The factors indicating nominal significant risk or protection are indicated in bold.

  • *HR (95% CI).