Table 3

Age-stratified observational and IV analysis based on a genetic score of the association of adiposity with cardiovascular risk factors

<55 years≥55 years
nβ (95% CI)P*PIV-obs*nβ (95% CI)P*PIV-obs*Pdiff*
Observational analyses
 Diastolic blood pressure71,5880.29 (0.26–0.32)2.7 × 10−9848,2100.23 (0.19–0.27)4.4 × 10−350.01
 Systolic blood pressure71,7530.25 (0.22–0.27)2.3 × 10−8548,5960.22 (0.18–0.26)2.0 × 10−260.19
 Fasting glucose45,0470.16 (0.13–0.20)7.3 × 10−2125,0890.24 (0.20–0.27)4.7 × 10−370.005
 2-h post-OGTT glucose13,7780.18 (0.10–0.25)3.1 × 10−68,4260.21 (0.09–0.32)4.6 × 10−40.66
 HbA1c14,8240.13 (0.07–0.20)1.1 × 10−414,3970.18 (0.12–0.24)8.8 × 10−90.35
 ln fasting insulin26,3220.48 (0.44–0.52)1.8 × 10−11814,8150.50 (0.45–0.54)1.6 × 10−970.57
 ln CRP41,8540.40 (0.37–0.43)2.5 × 10−17530,0900.30 (0.26–0.33)2.4 × 10−682.51 × 10−6
 ln IL-66,7190.16 (0.06–0.26)0.0015,1590.14 (0.08–0.21)1.9 × 10−50.73
 HDL-C57,672−0.28 (−0.30 to −0.27)1.1 × 10−30436,171−0.28 (−0.31 to −0.25)9.1 × 10−990.83
 LDL-C56,3920.16 (0.13–0.18)4.4 × 10−3331,4990.02 (0.00–0.04)0.089.73 × 10−16
 Total cholesterol69,7360.12 (0.10–0.15)9.8 × 10−2339,1120.00 (−0.02 to 0.02)0.961.0 × 10−12
 ln triglycerides68,7770.33 (0.31–0.35)4.3 × 10−22434,0610.27 (0.25–0.29)9.4 × 10−1812.4 × 10−5
 ln ALT27,9560.24 (0.18–0.30)1.1 × 10−1317,5170.19 (0.17–0.21)3.1 × 10−690.2
 ln GGT47,2020.25 (0.22–0.28)4.5 × 10−5024,6570.18 (0.16–0.20)4.5 × 10−655.5 × 10−4
IV analyses
 Diastolic blood pressure35,5180.21 (0.09–0.33)8.0 × 10−40.2032,5960.01 (−0.16 to 0.18)0.930.010.06
 Systolic blood pressure35,6810.21 (0.12–0.30)2.5 × 10−60.4132,9890.06 (−0.14 to 0.26)0.560.130.17
 Fasting glucose20,7420.10 (−0.01 to 0.22)0.090.2917,3800.04 (−0.11 to 0.19)0.580.010.54
 2-h post-OGTT glucose2,077−0.01 (−0.41 to 0.39)0.970.382,5190.13 (−0.27 to 0.53)0.530.710.64
 HbA1c13,6140.10 (−0.05 to 0.24)0.190.6513,2870.25 (0.01–0.48)0.040.580.29
 ln fasting insulin15,9850.26 (0.10–0.42)0.0010.019,5260.32 (0.12–0.52)0.0020.090.64
 ln CRP25,8220.35 (0.23–0.48)7.5 × 10−80.4821,9430.18 (0.01–0.35)0.040.170.10
 ln IL-65,3680.37 (0.12–0.61)0.0040.134,9170.13 (−0.13 to 0.40)0.320.960.21
 HDL-C32,977−0.36 (−0.47 to −0.25)3.4 × 10−100.2026,425−0.28 (−0.40 to −0.17)1.2 × 10−60.970.36
 LDL-C32,0160.15 (0.05–0.25)0.0040.9221,851−0.10 (−0.32 to 0.12)0.380.300.04
 Total cholesterol33,0020.10 (−0.05 to 0.24)0.200.7327,344−0.19 (−0.36 to −0.01)0.040.040.015
 ln triglycerides33,0180.28 (0.16–0.41)1.3 × 10−50.4522,4380.12 (0.00–0.25)0.050.020.09
 ln ALT11,2150.22 (0.05–0.39)0.010.8412,712−0.10 (−0.39 to 0.19)0.500.050.06
 ln GGT13,9150.24 (0.10–0.38)0.0010.8712,916−0.01 (−0.24 to 0.21)0.920.100.07
  • All models were adjusted for sex and age. β (95% CI), effect per SD change of BMI on trait (SD scale); Pdiff, difference between the two strata (only significant P values are shown); PIV-obs, P value from test of difference between observational and IV analyses.

  • *A nominal P value of <0.022 is considered significant at a 5% FDR level.