Table 2

Magnitudea of C-peptide suppression and counterregulatory responses

T1D subjects
Before islet transplantationAfter islet transplantationNondiabetic control subjects
n12128b
C-peptide (ng/mL)0.16 ± 0.020.13 ± 0.01
Glucagon (pg/mL)33 ± 360 ± 7**95 ± 13**
PP (pmol/L)32 ± 876 ± 23*160 ± 16**
Epinephrine (pg/mL)130 ± 16253 ± 21**419 ± 46**
Autonomic symptoms (∆)2.2 ± 0.95.3 ± 1.0§6.9 ± 2.4*
EGP (mg ⋅ kg−1 ⋅ min−1)0.59 ± 0.121.18 ± 0.13*1.42 ± 0.14**
Free fatty acids (μmol/L)50 ± 7161 ± 37*114 ± 18**
  • Data are mean ± SE. PP, pancreatic polypeptide.

  • aThe magnitude of each hormonal, EGP, free fatty acid, and incremental symptom response to the hypoglycemic clamps was assessed as the mean of values obtained during the last 60 min of each clamp.

  • bn = 6 for epinephrine.

  • *P < 0.05 for comparison with T1D subjects before transplantation.

  • **P < 0.01 for comparison with T1D subjects before transplantation.

  • §P = 0.06 for comparison with T1D subjects before transplantation.

  • P < 0.05 for comparison with T1D subjects after islet transplantation.

  • P < 0.01 for comparison with T1D subjects after islet transplantation.