Table 2

Nonstratified observational and IV analyses based on a genetic score of the association of adiposity with cardiovascular risk factors

Observational analysesIV analyses
nβ (95% CI)P*nβ (95% CI)P*PIV-obs*
Diastolic blood pressure117,2300.25 (0.23–0.27)2.5 × 10−13666,9970.15 (0.03–0.26)0.010.08
Systolic blood pressure117,7810.22 (0.20–0.24)2.3 × 10−10167,5530.16 (0.04–0.28)0.010.31
Fasting glucose69,1100.19 (0.15–0.22)2.9 × 10−2637,1810.09 (−0.01 to 0.19)0.070.06
2-h post-OGTT glucose22,2040.19 (0.11–0.27)5.9 × 10−64,5960.11 (−0.19 to 0.40)0.480.61
HbA1c29,4510.16 (0.11–0.21)5.1 × 10−1026,9010.19 (0.01–0.36)0.030.79
ln fasting insulin40,1650.48 (0.44–0.52)1.2 × 10−12724,6140.31 (0.17–0.45)9.6 × 10−60.02
ln CRP71,9600.33 (0.30–0.36)2.7 × 10−10247,7810.30 (0.20–0.41)8.8 × 10−90.56
ln IL-611,8780.13 (0.06–0.19)2.0 × 10−410,2850.26 (0.08–0.45)0.010.18
HDL-C93,015−0.28 (−0.29 to −0.26)5.8 × 10−21158,387−0.33 (−0.42 to −0.24)1.1 × 10−120.29
LDL-C86,7930.11 (0.08–0.14)5.7 × 10−1752,8580.08 (−0.02 to 0.19)0.110.64
Total cholesterol107,7410.08 (0.06–0.10)9.7 × 10−1559,3290.00 (−0.11 to 0.11)0.970.17
ln triglycerides101,7090.31 (0.30–0.32)<1 × 10−30054,4170.23 (0.12–0.34)2.7 × 10−50.18
ln ALT45,4730.23 (0.19–0.26)6.5 × 10−3123,9270.09 (−0.09 to 0.26)0.320.13
ln GGT71,8590.22 (0.20–0.24)4.3 × 10−8726,8310.15 (0.00–0.29)0.040.35
  • All models were adjusted for sex and age. β (95% CI), effect per SD change of BMI on trait (SD scale); PIV-obs, P value from test of difference between observational and IV analyses.

  • *A nominal P value of <0.022 is considered significant at a 5% FDR level.