Table 1

High-risk HLA genotypes constituting the criteria for eligibility for FDRs and children from the GP into the TEDDY study

Code in TEDDYGenotypesAbbreviationGP
ADRB1*04-DQA1*03-DQB1*03:02/DRB1*03-DQA1*05-DQB1*02:01DR3/4Yes
BDRB1*04-DQA1*03-DQB1*03:02/DRB1*04-DQA1*03-DQB1*03:02DR4/4Yes
CDRB1*04-DQA1*03-DQB1*03:02/DRB1*08-DQA1*04-DQB1*04:02DR4/8Yes
DDRB1*03-DQA1*05-DQB1*02:01/DRB1*03-DQA1*05-DQB1*02:01DR3/3Yes
EDRB1*04-DQA1*03-DQB1*03:02/DRB1*04-DQA1*03-DQB1*02:02DR4/4No
FDRB1*04-DQA1*03-DQB1*03:02/DRB1*01-DQA1*01-DQB1*05:01DR4/1No
GDRB1*04-DQA1*03-DQB1*03:02/DRB1*13-DQA1*01-DQB1*06:04DR4/13No
HDRB1*04-DQA1*03-DQB1*03:02/DRB1*04-DQA1*03-DQB1*03:04DR4/4No
IDRB1*04-DQA1*03-DQB1*03:02/DRB1*09-DQA1*03-DQB1*03:03DR4/9No
JDRB1*03-DQA1*05-DQB1*02:01/DRB1*09-DQA1*03-DQB1*03:03DR3/9No
  • Genotypes A, B, C, and D confer GP eligibility but exclude DRB1*04:03. Genotypes A through J confer eligibility to an FDR of a diabetic patient.

  • †Where DQB1*03:02 is noted, either allele or DQB1*03:04 is allowed, see Hagopian et al. (14).