NRI based on addition of gene score to FORS, calculated using risk cutoffs of 5, 10, and 15% for 10-year risk
| Predicted risk FORS | Number of people | Reclassified | Net correctly reclassified | ||||
|---|---|---|---|---|---|---|---|
| ≤5 | 5–9.9 | 10–14.9 | ≥15 | Increased risk | Decreased risk | ||
| A. For the whole cohort | |||||||
| Plus externally weighted gene score: no diabetes (n = 18,715.81) | 1,782.23 | 2,138.63 | 1.9% (1.2–32.6) | ||||
| <5 | 10,406.62 | 582.00 | 36.28 | 0 | |||
| 5–9.9 | 1,064.52 | 1,967.29 | 542.56 | 118.24 | |||
| 10–14.9 | 35.16 | 647.23 | 682.39 | 503.15 | |||
| ≥15 | 6.55 | 78.89 | 306.28 | 1,738.65 | |||
| Plus externally weighted gene score: incident diabetes (n = 1,121.86) | 185.96 | 116.49 | 6.2% (3.2–9.2) | ||||
| <5 | 279.01 | 34.13 | 1 | 0 | |||
| 5–9.9 | 36.80 | 81.20 | 55.97 | 15.82 | |||
| 10–14.9 | 0 | 45.93 | 71.24 | 79.04 | |||
| ≥15 | 0 | 11.73 | 22.03 | 387.96 | |||
| B. BMI tertile 1 (BMI <24.5) | |||||||
| Plus externally weighted gene score: no diabetes (n = 6,267.82) | 448.8 | 616.52 | 2.7% (1.7–3.7) | ||||
| <5 | 4,202.14 | 95.95 | 2 | 0 | |||
| 5–9.9 | 540.06 | 834.1 | 232.65 | 63.3 | |||
| 10–14.9 | 1 | 35.27 | 36.08 | 54.9 | |||
| ≥15 | 0 | 7.13 | 33.06 | 130.18 | |||
| Plus externally weighted gene score: incident diabetes (n = 147.53) | 45.88 | 9.13 | 24.9% (15.0–34.8) | ||||
| <5 | 56 | 3 | 0 | 0 | |||
| 5–9.9 | 6.13 | 21.06 | 26.32 | 7.82 | |||
| 10–14.9 | 0 | 3 | 2.21 | 8.74 | |||
| ≥15 | 0 | 0 | 0 | 13.25 | |||
| C. BMI tertile 2 (BMI 24.5–27.4) | |||||||
| Plus externally weighted gene score: no diabetes (n = 6,526.66) | 706.02 | 715.15 | 0.1% (−1.0 to 1.3) | ||||
| <5 | 3,684.61 | 267.53 | 22.95 | 0 | |||
| 5–9.9 | 339.91 | 675.31 | 185.82 | 34.24 | |||
| 10–14.9 | 20.83 | 253.93 | 266.22 | 195.48 | |||
| ≥15 | 6.55 | 22.56 | 71.37 | 479.35 | |||
| Plus externally weighted gene score: incident diabetes (n = 308.31) | 58.26 | 22.93 | 11.5% (5.7–17.2) | ||||
| <5 | 112.17 | 17.13 | 0 | 0 | |||
| 5–9.9 | 7.13 | 23.63 | 12.25 | 6 | |||
| 10–14.9 | 0 | 11.66 | 18.64 | 22.88 | |||
| ≥15 | 0 | 1 | 3.14 | 72.68 | |||
| D. BMI tertile 3 (BMI ≥27.5) | |||||||
| Plus externally weighted gene score: no diabetes (n = 5,921.35) | 627.42 | 806.96 | 3.0% (1.8–4.3) | ||||
| <5 | 2,519.87 | 218.52 | 11.33 | 0 | |||
| 5–9.9 | 184.55 | 457.88 | 124.09 | 20.71 | |||
| 10–14.9 | 13.33 | 358.03 | 380.1 | 252.77 | |||
| ≥15 | 0 | 49.2 | 201.85 | 1,129.12 | |||
| Plus externally weighted gene score: incident diabetes (n = 666.02) | 81.82 | 84.43 | −0.4% (−4.2 to 3.4) | ||||
| <5 | 110.83 | 14 | 1 | 0 | |||
| 5–9.9 | 23.55 | 36.52 | 17.4 | 2 | |||
| 10–14.9 | 0 | 31.26 | 50.39 | 47.42 | |||
| ≥15 | 0 | 10.73 | 18.89 | 302.03 | |||
A. Values are weighted to take into account sampling design, thus accounting for the fact that the number of individuals is not an integer. P value for heterogeneity = 0.002. I2 = 71.1%. NRI (95% CI) = 8.1% (5.0–11.2), no adjustment for study; P = 3.31 × 10−7. NRI (95% CI) = 6.6% (3.6–9.7), results from meta-analysis of individual study results (fixed effects); P = 2.0 × 10−5. NRI (95% CI) = 7.7% (1.7–13.8), results from meta-analysis of individual study results (random effects); P = 0.01. B. NRI (95% CI) = 27.6% (17.7–37.5); P = 4.82 × 10–8. C. NRI (95% CI) = 11.6% (5.8–17.4); P = 9.88 × 10–5. D. Values are weighted to take into account sampling design, thus accounting for the fact that the number of individuals is not an integer. NRI (95% CI) = 2.6% (−1.4 to 6.6); P = 0.20.