Table 2

Metabolic parameters during the OGTT in the IS and IR groups

IS (n = 64)IR (n = 79)P
FPG (mmol/L)4.83 ± 0.055.07 ± 0.07**
FPI (pmol/L)52 (30)86 (54)***
AUCG (mol · L−1 · h)1.02 ± 0.021.26 ± 0.03***
AUCI (mol · L−1 · h)40.9 ± 2.686.3 ± 5.9***
AUCFFA (mol · L−1 · h)44.2 ± 1.754.2 ± 2.5**
ISR5mM (pmol · min−1 · m−2)85 (44)117 (52)**
Total IS (nmol · m−2)46 (22)68 (25)***
β-GS (pmol · min−1 · m−2 · [mmol/L]−1 )108 (63)102 (56)ns
Rate sensitivity (nmol · m−2 · [mmol/L]−1)1.16 (0.84)1.26 (0.87)ns
Potentiation (ratio)1.52 (0.70)1.33 (0.42)**
  • Data are means ± SE or median (interquartile range). Potentiation (ratio) = (1–14 h)/(0–20 min). AUCG, glucose AUC; AUCI, insulin AUC; β-GS, β-cell glucose sensitivity; FPG, fasting plasma glucose; FPI, fasting plasma insulin; ISR5mM, insulin secretion at 5 mmol/L glucose; ns, not significant; total IS, total insulin secretion.

  • †χ2 or Mann-Whitney test for group differences;

  • **P < 0.01;

  • ***P < 0.001.