Table 1

Neuroendocrine responses and NEFA responses during euglycemic and hypoglycemic clamps

Day 1 euglycemiaDay 2 hypoglycemia
after day 1 euglycemiaDay 1 hypoglycemiaDay 2 hypoglycemia
after day 1 hypoglycemia
BasalFinalBasalFinalBasalFinalBasalFinal
Epinephrine (pmol/L)190 ± 20189 ± 20179 ± 204,251 ± 568*184 ± 403,741 ± 465*198 ± 302,497 ± 265*
Norepinephrine (pmol/L)1,083 ± 801,159 ± 771,128 ± 1241,957 ± 134*1,057 ± 1191,966 ± 149*1,161 ± 1242,028 ± 184*
Cortisol (nmol/L)344 ± 31292 ± 30330 ± 32714 ± 42*359 ± 34850 ± 70*271 ± 26572 ± 62*
Glucagon (ng/L)65 ± 543 ± 3*50 ± 6112 ± 17*57 ± 4164 ± 26*44 ± 790 ± 13*
GH (ng/mL)2.5 ± 0.42.4 ± 0.44 ± 1.3425 ± 5*3.1 ± 0.528 ± 5*2.2 ± 0.220 ± 3*
NEFA (mmol/L)379 ± 48103 ± 40*382 ± 5597 ± 14*288 ± 32110 ± 19*351 ± 2898 ± 23*
  • Data are means ± SE. GH, growth hormone.

  • *P < 0.05, significantly different from baseline.

  • P < 0.05, significantly different from day 1 euglycemia.

  • P < 0.05, significantly different from day 1 hypoglycemia.