Table 2

Circulating lipid levels and hepatic and skeletal muscle glycogen content in Stk25 KO mice and WT littermates

ParameterWT CDKO CDWT HFDKO HFD
Plasma triacylglycerol (mmol/L)0.19 ± 0.010.22 ± 0.020.31 ± 0.03††0.26 ± 0.03
Plasma cholesterol (mmol/L)2.35 ± 0.082.30 ± 0.072.46 ± 0.092.52 ± 0.06#
Plasma β-hydroxybutyrate (mmol/L)0.88 ± 0.060.87 ± 0.030.80 ± 0.040.83 ± 0.06
Hepatic glycogen (μg/mg)1.06 ± 0.060.92 ± 0.01*2.85 ± 0.15††2.42 ± 0.05*,##
Muscle glycogen (μg/mg)0.76 ± 0.030.64 ± 0.03*0.55 ± 0.04††0.43 ± 0.03*,##
  • Data are mean ± SEM from 10–12 mice per genotype and diet group. The blood lipid levels and tissue glycogen content were measured in mice fed an HFD for 20 weeks compared with age-matched CD groups. CD, chow diet; HFD, high-fat diet; KO, knockout; WT, wild type.

  • *P < 0.05 for Stk25−/− mice vs. corresponding WT littermates;

  • ††P < 0.01 for WT mice fed HFD vs. CD;

  • #P < 0.05 for Stk25−/− mice fed HFD vs. CD;

  • ##P < 0.01 for Stk25−/− mice fed HFD vs. CD.