Table 2

Top upregulated and downregulated genes in the obese compared with the lean co-twins (n = 26 discordant pairs)

SymbolDescriptionAdjusted P valueFC
Upregulated genes
 VAMP8 Vesicle-associated membrane protein 80.00411.51
 HSPB7 Heat shock 27-kDa protein family, member 7 (cardiovascular)0.01081.47
 FTH1 Ferritin, heavy polypeptide 10.00031.41
 TOMM40L Translocase of outer mitochondrial membrane 40 homolog (yeast)-like0.00121.38
 TMEM160 Transmembrane protein 1600.00371.33
 PLA2G15 Phospholipase A2, group XV0.01321.32
 TXNRD1 Thioredoxin reductase 10.00161.30
 SLC25A43 Solute carrier family 25, member 430.00181.24
Downregulated genes
 NIPSNAP3B Nipsnap homolog 3B (Caenorhabditis elegans)0.0002−1.92
 LDHD Lactate dehydrogenase D0.0025−1.71
 ALDH1L1 Aldehyde dehydrogenase 1 family, member L10.0010−1.62
 AASS Aminoadipate-semialdehyde synthase0.0006−1.59
 GPT2 Glutamic pyruvate transaminase (alanine aminotransferase) 20.0010−1.58
 ECHDC3 Enoyl-CoA hydratase domain containing 30.0006−1.56
 ALDH6A1 Aldehyde dehydrogenase 6 family, member A10.0006−1.56
 C10orf10 Chromosome 10 open reading frame 100.0186−1.54
 PXMP2 Peroxisomal membrane protein 2, 22 kDa0.0004−1.52
 ACP6 Acid phosphatase 6, lysophosphatidic0.0022−1.48
 PC Pyruvate carboxylase0.0015−1.41
 ECI1 Enoyl-CoA delta isomerase 10.0002−1.41
 PCCB Propionyl CoA carboxylase, β-polypeptide0.0006−1.38
 SHMT1 Serine hydroxymethyltransferase 1 (soluble)0.0016−1.38
 ACACA Acetyl-CoA carboxylase-α0.0042−1.37
 LIAS Lipoic acid synthetase0.0010−1.36
 PCK2 Phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.0141−1.35
 HADH Hydroxyacyl-CoA dehydrogenase0.0002−1.34
  • FC, fold change.