Table 3

Median percent abundances of bacterial taxa in subjects with one versus multiple autoantibodies

TaxaaOne autoantibody (n = 5)Two to four autoantibodies (n = 16)Unadjusted P valueb
Bacteria/Bacteroidetes/Bacteroidia/Bacteroidales/Bacteroidaceae/Bacteroides6.37 (5.67–6.96)35.62 (13.20–49.29)0.01
Bacteria/Bacteroidetes/Bacteroidia/Bacteroidales/Prevotellaceae/Prevotella12.91 (9.62–26.77)0.05 (0.01–1.82)0.01
Bacteria/Bacteroidetes/Bacteroidia/Bacteroidales/Porphyromonadaceae/Butyricimonas0.53 (0.28–0.54)0.23 (0.00–0.33)0.03
Bacteria/Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Coprococcus1.37 (0.62–2.16)0.26 (0.09–1.02)0.03
Bacteria/Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Butyrivibrio0.08 (0.04–0.44)0.00 (0.00–0.00)<0.01
Bacteria/Verrucomicrobia/Verrucomicrobiae/Verrucomicrobiales/Verrucomicrobiaceae/Akkermansia0.06 (0.02–0.08)0.74 (0.15–4.46)0.04
  • Data are median relative abundance of 16S rRNA sequences for bacterial clade. Shown in parentheses are the ranges of the bacterial abundance.

  • aPhylogeny of bacterial genera, assigned by 16S rRNA sequencing analysis.

  • bResults from Wilcoxon rank-based test.