Table 5

Upstream transcription factors regulating the mitochondrial-related genes (IPA of the differentially expressed genes, n = 26 discordant pairs)

Upstream regulatorPredicted activation stateActivation z scoreP value of overlapTarget molecules in the dataset
FOXO1Inhibited−3.1624.42e-06↓ ACACA, ↓ ATP5B, ↓ MAVS, ↓ MRPL45, ↓ MRPL46, ↓ MRPL57, ↓ MRPS18A, ↓ MRPS2, ↓ MRPS22, ↓ MRPS30, ↓ MRPS7, ↓ NDUFA12, ↓ NDUFA8, ↓ PDHB
PPARGC1AInhibited−2.8233.28e-09↓ ACACA, ↓ ACACB, ↓ ACADM, ↑ ALAS1, ↓ ATP5B, ↓ ATP5O, ↓ COX4I1, ↓ NDUFB5, ↓ NDUFS1, ↓ PDK4, ↓ TXN2
KMT2DInhibited−2.2360.0272↓ ACADM, ↓ ECI2, ↓ HDDC2, ↓ OXR1, ↓ SFXN4
PPARGC1BInhibited−2.2197.19e-06↓ ACACA, ↓ ACACB, ↓ ACADM, ↓ COX4I1, ↓ PDK4
KLF15Inhibited−2.1211.29e-09↓ ACADM, ↓ DECR1, ↓ HADHA, ↓ HADHB, ↓ MLYCD, ↓ PDK4, ↓ PXMP2, ↑ SLC25A20
HNF1AInhibited−2.0000.0062↓ CCBL2, ↓ COQ7, ↓ FH, ↑ GARS, ↓ MCCC1, ↓ PDK1, ↓ SFXN2, ↓ UQCRC2
  • ↓, downregulated in the obese compared with the lean co-twins; ↑, upregulated in the obese compared with the lean co-twins.