Table 3

Highlighted loci results for MTIF3 (rs1885988) and weight loss over 4 years in the full sample and FUBP1 (rs12401738) and weight regain across years 2–4 among those who lost 3% or more of their baseline weight at year 1

VariantEffectYearIndividual study resultsMeta-analysis
Look AHEADDPPDifferences in estimates (LA − DPP)Matrix-weighted averages (LA + DPP)
PE (95% CI)PPE (95% CI)PPE (95% CI)PPE (95% CI)P
MTIF3 (rs1885988)Lifestyle1−0.73 (−1.30, −0.15)0.009−0.66 (−1.45, 0.13)0.22−0.07 (−1.04, 0.91)0.62−0.70 (−1.16, −0.24)0.002
2−0.95 (−1.62, −0.27)−0.65 (−1.55, 0.25)−0.30 (−1.42, 0.83)−0.83 (−1.37, −0.29)
3−1.18 (−1.93, −0.42)−1.10 (−2.14, −0.06)−0.08 (−1.36, 1.21)−1.14 (−1.75, −0.53)
4−0.54 (−1.33, 0.25)−1.48 (−3.03, 0.08)0.94 (−0.80, 2.68)−0.63 (−1.30, 0.05)
Comparison1−0.36 (−0.94, 0.22)0.090.68 (−0.15, 1.51)0.34−1.04 (−2.05, −0.03)0.26−0.02 (−0.50, 0.45)0.11
2−0.69 (−1.36, −0.01)0.60 (−0.34, 1.54)−1.29 (−2.44, −0.13)−0.25 (−0.80, 0.29)
3−0.06 (−0.82, 0.70)1.10 (−0.02, 2.21)−1.15 (−2.50, 0.20)0.33 (−0.30, 0.95)
4−0.07 (−0.87, 0.72)0.73 (−1.13, 2.60)−0.81 (−2.83, 1.22)0.24 (−0.46, 0.94)
Lifestyle - Comparison1−0.37 (−1.18, 0.44)0.08−1.34 (−2.48, −0.20)0.0480.97 (−0.43, 2.38)0.62−0.69 (−1.36, −0.03)0.004
2−0.26 (−1.21, 0.69)−1.25 (−2.55, 0.05)0.99 (−0.62, 2.60)−0.59 (−1.36, 0.17)
3−1.12 (−2.19, −0.05)−2.20 (−3.72, −0.67)1.08 (−0.78, 2.94)−1.48 (−2.35, −0.61)
4−0.46 (−1.58, 0.66)−2.21 (−4.63, 0.21)1.75 (−0.92, 4.42)−0.85 (−1.82, 0.12)
FUBP1 (rs12401738)Lifestyle2−0.12 (−0.51, 0.27)0.240.51 (−0.04, 1.06)0.27−0.63 (−1.30, 0.05)0.330.09 (−0.23, 0.41)0.2
30.06 (−0.48, 0.59)0.70 (−0.16, 1.57)−0.65 (−1.66, 0.37)0.26 (−0.19, 0.72)
4−0.36 (−0.96, 0.25)0.41 (−1.04, 1.86)−0.76 (−2.33, 0.80)−0.16 (−0.70, 0.38)
Comparison2−0.81 (−1.55, −0.07)0.13−0.91 (−1.92, 0.10)0.320.10 (−1.15, 1.35)0.99−0.84 (−1.44, −0.25)0.03
3−1.12 (−2.13, −0.10)−1.22 (−2.77, 0.32)0.11 (−1.74, 1.96)−1.15 (−2.00, −0.30)
4−0.93 (−2.07, 0.21)−0.98 (−3.84, 1.89)0.05 (−3.04, 3.13)−0.96 (−1.98, 0.06)
Lifestyle - Comparison20.69 (−0.14, 1.52)0.181.42 (0.28, 2.56)0.08−0.73 (−2.14, 0.69)0.790.94 (0.27, 1.61)0.01
31.17 (0.02, 2.32)1.93 (0.16, 3.69)−0.76 (−2.87, 1.35)1.42 (0.46, 2.38)
40.58 (−0.71, 1.86)1.39 (−1.82, 4.6)−0.81 (−4.27, 2.65)0.80 (−0.35, 1.96)
  • Point estimates (PE) and 95% CI represent weight change (kg) per minor allele (MTIF3-rs1885988 G allele; FUBP1-rs12401738 A allele, respectively). Longitudinal regression models adjusted for baseline weight, age, sex, ancestry (principal components 1–3), and study site. P values were obtained using multiyear χ2 tests for the corresponding effect estimate. LA, Look AHEAD.