Table 3

Surface regions with significant between group differences in longitudinal gray matter change over 18 months

Cluster size (mm2)Peak t scorePeak MNI location (x, y, z)*P value**
Volume (control subjects > children with type 1 diabetes)
 L precentral, middle frontal2,8364.86−52, −10, 220.0001
 L inferior parietal, supramarginal2,4633.02−49, −53, 310.0001
 L superior frontal1,6382.66−7, 57, 190.0004
 L fusiform8963.49−38, −75, −80.05
 R frontal lobe11,6713.9651, 16, 160.0001
 R postcentral, superior temporal5,7175.3447, −27, 370.0001
 R posterior middle temporal1,5743.3150, −59, 70.001
 R caudal middle frontal1,4322.9232, 7, 500.002
SA (control subjects > children with type 1 diabetes)
 R temporal pole2,0775.3027, 7, −310.0001
 R pars triangularis8473.9742, 31, −50.005
 R lateral orbitofrontal1,9013.0020, 45, −130.0001
 R pars opercularis1,0983.8648, 7, 20.0003
Thickness*** (control subjects > children with type 1 diabetes)
 L supramarginal1,1853.40−56, −42, 300.014
 R supramarginal, superior temporal3,3264.2047, −26, 360.0001
 R lateral inferior frontal lobe5,5874.0553, 17, 150.0001
 R precentral2,2712.8729, −2, 410.0001
  • L, left; R, right.

  • *Peak vertex coordinates are in MNI space.

  • **All P values are cluster extent corrected for family-wise error.

  • ***Type 1 diabetes had more cortical thinning than control subjects.