Table 2

Growth differences of regional volumes and global surface properties

Control subjectsType 1 diabetesGrowth difference (control subjects > diabetes subjects)
Time1Time2Time1Time2P value
Cortical surface
 Cortical volume (1,000 mm3)590 (42)591 (42)588 (45)586 (46)0.046
 Total SA (1,000 mm2)178.2 (13)179.1 (13)177.5 (15)177.9 (15)0.03
 Mean CT (mm)2.89 (0.09)2.86 (0.09)2.90 (0.09)2.86 (0.08)NS
 Mean curvature0.168 (0.006)0.169 (0.007)0.168 (0.007)0.169 (0.007)NS
Brain volumes (1,000 mm3)
 Total gray matter759 (51)762 (50)756 (55)754 (55)0.05
 Total white matter427 (45)442 (45)425 (47)437 (49)0.003
 Basal ganglia total59.4 (4.8)60.2 (4.8)59.0 (4.6)59.7 (4.6)NS
 Cerebral white matter (lh)190 (21)196 (21)189 (22)194 (22)0.049
 Cerebral white matter (rh)190 (21)196 (21)189 (22)194 (22)0.004
 Corpus callosum2.70 (0.35)2.80 (0.35)2.72 (0.38)2.80 (0.39)0.001
 Ventricular volume11 (5.3)11 (5.6)11 (4.9)11 (4.9)NS
 Cerebellar gray matter (lh)54.0 (45)54.8 (4.4)53.4 (5.0)54.0 (4.8)NS
 Cerebellar gray matter (rh)55.3 (45)55.9 (4.4)54.6 (5.1)55.1 (5.1)NS
 Cerebellar white matter (lh)12.9 (1.4)13.7 (1.4)12.7 (1.6)13.2 (1.6)0.014
 Cerebellar white matter (rh)13.3 (1.5)14.0 (1.5)12.8 (1.5)13.4 (1.6)0.018
 Brain stem (pons, midbrain)18.4 (1.9)19.2 (1.9)18.3 (2.0)18.9 (2.0)0.003
  • Data are reported as the mean (SD). lh, left hemisphere; NS, not significant; rh, right hemisphere.