Table 2

Replicated SNP associations with additional kidney function and diabetes-related traits

TraitnEffect (OR)SEP valueP difference*
rs649529, RAB38/CTSC
UACR, diabetes; log(mg/g)7,787−0.140.035.8 × 10−76.9 × 10−6
UACR, no diabetes; log(mg/g)45,094−0.0040.0080.64
eGFRcrea, diabetes; log(mL/min/1.73 m2)11,5270.0030.0040.462.8 × 10−1
eGFRcrea, no diabetes; log(mL/min/1.73 m2)118,427−0.0010.0010.59
CKD (eGFR <60 mL/min/1.73 m2)118,114(1.01)0.020.57
Type 2 diabetes63,390(1.02)0.020.32
Fasting glucose (mmol/L)46,1860.0030.0060.65
HbA1c (%)46,3680.0040.0040.31
rs13427836, HS6ST1
UACR, diabetes; log(mg/g)7,3990.190.046.3 × 10−71.7 × 10−5
UACR, no diabetes; log(mg/g)34,8300.0100.0120.38
eGFRcrea, diabetes; log(mL/min/1.73 m2)11,0920.0080.0060.131.3 × 10−1
eGFRcrea, no diabetes; log(mL/min/1.73 m2)114,2470.0000.0010.94
CKD (eGFR <60 mL/min/1.73m2)113,612(0.97)0.020.23
Type 2 diabetes63,390(1.00)0.030.94
Fasting glucose (mmol/L)46,186−0.0050.0040.22
HbA1c (%)46,3680.0030.0050.61
rs10795433, CUBN
UACR, diabetes; log(mg/g)5,8250.190.042.0 × 10−58.2 × 10−4
UACR, no diabetes; log(mg/g)46,0610.0450.018.7 × 10−6
eGFRcrea, diabetes; log(mL/min/1.73 m2)11,5220.0070.0050.181.9 × 10−1
eGFRcrea, no diabetes; log(mL/min/1.73 m2)118,2990.00070.0010.61
CKD (eGFR <60 mL/min/1.73 m2)118,121(1.04)0.020.08
Type 2 diabetes63,390(1.00)0.030.88
Fasting glucose (mmol/L)46,186−0.0030.0050.52
HbA1c (%)46,368−0.0020.0050.73
  • DM, diabetes mellitus; eGFRcrea, GFR estimated by serum creatinine levels; OR, odds ratio.

  • Effects represent the change in trait associated with each additional copy of the minor allele for each of the SNPs. For continuous traits, units are provided; the effect for binary outcomes, shown in parentheses, represents the OR. Except for UACR in diabetes, estimates refer to the discovery samples of the respective trait and to the published resources for the glycemic traits. Fasting glucose and HbA1c were evaluated among individuals free of diabetes. For the kidney traits, P values and SEs are corrected using genomic control.

  • *P value for difference from a two-sample t test: t = (effectDM − effectnonDM)/(SEDM2 + SEnonDM2)0.5 which, for large sample sizes is distributed as a normal (0,1). The correlation between effectDM and effectnonDM is assumed to be 0.

  • Associations with type 2 diabetes were tested using the publicly available summary statistics dataset from the DIAGRAM (DIAbetes Genetics Replication And Meta-analysis) Consortium (12,171 case subjects and 56,862 control subjects) (40). Associations with fasting glucose and plasma hemoglobin A1c concentrations were evaluated using the publicly available results from the MAGIC Consortium (www.magicinvestigators.org) (41,42).

  • †UACR effect estimates for UACR in diabetes for CUBN are provided from the discovery stage.