Table 2

Fatty acid composition of the hypothalamus as analyzed by gas chromatography (% of total fat)

Fatty acidNFDHFDHFD n-3
C16:022.87 ± 1.3722.30 ± 1.3024.44 ± 1.33
C18:021.41 ± 0.5520.63 ± 0.2021.41 ± 0.93
C22:00.24 ± 0.040.28 ± 0.06*0.23 ± 0.13#
ΣSFA44.91 ± 1.9244.30 ± 1.1444.66 ± 1.12
C16:10.80 ± 0.030.75 ± 0.030.82 ± 0.04
C18:1 (n-9)25.01 ± 1.6625.20 ± 0.5524.66 ± 1.23
ΣMUFA26.55 ± 0.1629.44 ± 0.45*26.79 ± 0.32#
C18:2 (n-6)1.93 ± 0.772.44 ± 0.111.76 ± 0.09
C18:3 (n-3)0.06 ± 0.020.08 ± 0.020.22 ± 0.02*#
C20:4 (n-6)10.17 ± 0.809.77 ± 0.6010.29 ± 0.64
C20:5 (n-3)0.23 ± 0.060.31 ± 0.03*0.20 ± 0.04#
C22:5 (n-3)0.28 ± 0.170.15 ± 0.15*0.23 ± 0.12#
C22:6 (n-3)15.98 ± 0.7715.32 ± 0.5816.93 ± 0.54
ΣPUFA28.55 ± 0.9425.35 ± 0.55*28.42 ± 1.21#
  • ΣSFA includes C8:0, C10:0, C12:0, C14:0, C16:0, C18:0, C20:0 and C22:0. ΣMUFA includes C14:1, C16:1, C17:1,C18:1, C20:1 and C24:1. ΣPUFA includes C18:2, C18:3, C20:2, C20:3, C20:4, C20:5, C22:5, C55:6. In all measurements, n = 5. HFD n-3, HFD with 20% substitution by flaxseed oil; SFA, saturated fatty acid; MUFA monounsaturated fatty acid; PUFA, polyunsaturated fatty acid.

  • *P < 0.05 vs. NFD;

  • #P < 0.05 vs. HFD.