Table 5

Haplotypic association analysis of DRB1 and DRB3 or DRB4 (DRB345) haplotypes with five islet autoantibodies (IAA, GADA, IA-2A, ZnT8RA, ZnT8WA, ZnT8QA) among all 448 patients, with the most common haplotype DRB1*04:01:01-DRB4*01:03:01 as the reference

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  • The yellow highlights indicate differences in haplotypic associations for ZnT8RA and ZnT8QA whether the DRB3 is either *01:01:02 or *02:02:01 on the DRB1*03:01:01 haplotype. Similarly, GADA and IA-2A vary dependent on the DRB4 subtype on the DRB1*07:01:01 haplotype. Association statistics are coefficients, SEs, z scores, and P values. Hap freq, haplotype frequency; t stat, t statistic.