Table 2

Family-based haplotype association analysis of PTPN22

Haplotypess538819444rs371865329rs2476601rs74163663rs56048322FrequencyFamily (n)Z scoreP value
H1222220.8721,072−12.981.68E-38
H2221220.1191,01212.241.81E-34
H3222210.008923.190.0014
H4221120.00172.190.028
H512222<0.00120.450.65
H621222<0.00111.000.32

  • 1, minor allele; 2, major allele; n, number of informative families.